Protein kinase C modulation.

H H Grunicke; F Uberall

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PubMed · 1286156

Protein kinase C modulation.

H H Grunicke·F Uberall

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Abstract

PKC-modulators represent valuable additions to the arsenal of anti-tumor agents. They act as antiproliferative agents and are useful in overcoming drug-resistance by inhibiting mdr-mediated drug efflux. They increase the cytotoxicity to platinum complexes (and other DNA-damaging agents), probably by interfering with drug-induced detoxification and repair mechanisms. PKC-modulators are potentially active in overcoming ras-induced cis-platinum-resistance by antagonizing p21ras functions.

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Antineoplastic Agents Humans Protein Kinase C Journal Article Research Support, Non-U.S. Gov't Review

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H H Grunicke, F Uberall. 1992. Protein kinase C modulation.. https://pubmed.ncbi.nlm.nih.gov/1286156/

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