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Improving the evidence-base in surgery: evaluating surgical effectiveness.

Abstract

This second of two articles about clinical epidemiology reviews the generation and synthesis of evidence for the effectiveness of surgical procedures. While well-designed randomized controlled trials of surgical procedures are considered the 'gold standard' of evaluation design, they may achieve high internal validity at the expense of external validity (generalizability). Improving the -evidence-base in surgery likely will require a comprehensive approach to surgical outcomes assessment, involving both improvements in the quality and quantity of randomized controlled trials as well as recognition of the complementary role of alternate study designs.

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BibTeXRIS

Jane M Young, Michael J Solomon. 2003. Improving the evidence-base in surgery: evaluating surgical effectiveness.. https://doi.org/10.1046/j.1445-1433.2003.02662.x

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Theseus: fast and optimal affine-gap sequence-to-graph alignment.

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