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Major histocompatibility complex-dependent susceptibility to Cryptococcus neoformans in mice.

Erin E McClelland·Donald L Granger·Wayne K Potts
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Abstract

To evaluate the role of major histocompatibility complex (MHC) genes in the resistance to Cryptococcus neoformans, we conducted infection experiments in MHC-congenic strains of mice. Significant MHC-dependent susceptibility differences were found among homozygotes and heterozygotes. This study is the first experimental demonstration of MHC-dependent susceptibility to C. neoformans infections in mice and indicates that MHC genes can be important in host resistance.

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AnimalsColony Count, MicrobialCryptococcosisCryptococcus neoformansFemaleGenotypeH-2 AntigensHaplotypesHeterozygoteHomozygoteLiverMajor Histocompatibility ComplexMiceMice, CongenicMice, Inbred BALB CMice, Inbred C57BLSpecies SpecificityComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Erin E McClelland, Donald L Granger, Wayne K Potts. 2003. Major histocompatibility complex-dependent susceptibility to Cryptococcus neoformans in mice.. https://doi.org/10.1128/iai.71.8.4815-4817.2003

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