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Equilibrium protein folding-unfolding process involving multiple intermediates.

Hui-Chih Hung·Yu-Hou Chen·Guang-Yaw Liu·Hwei-Jen Lee·Gu-Gang Chang
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Abstract

Mathematical models for the protein folding-unfolding process involving multiple intermediates have been derived. Computer fitting of the experimental data to this model generates various thermodynamic parameters for the folding-unfolding process. In this way, the complex folding-unfolding process of the multi-domain proteins can be analysed in a quantitative way. The application of the folding-unfolding model involving seven stages in human placental alkaline phosphatase is described.

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Alkaline PhosphataseComputer SimulationFemaleHumansKineticsModels, ChemicalPlacentaProtein FoldingJournal ArticleResearch Support, Non-U.S. Gov't

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Hui-Chih Hung, Yu-Hou Chen, Guang-Yaw Liu, Hwei-Jen Lee, Gu-Gang Chang. 2003. Equilibrium protein folding-unfolding process involving multiple intermediates.. https://doi.org/10.1016/s0092-8240(03)00024-7

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