A biocompatible needle-type glucose sensor based on platinum-electroplated carbon electrode.

C Y Chen; E Tamiya; K Ishihara; Y Kosugi; Y C Su; N Nakabayashi; I Karube

doi:10.1007/bf02921780

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A biocompatible needle-type glucose sensor based on platinum-electroplated carbon electrode.

C Y Chen·E Tamiya·K Ishihara·Y Kosugi·Y C Su·N Nakabayashi·I Karube

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Abstract

A biocompatible needle-type glucose sensor with a 3-electrode configuration was constructed. A platinum-electroplated carbon stick was used as the working electrode, Ag/AgCl as the reference electrode, and a disposable hypodermic needle made of stainless steel as the counter electrode. A Nafion membrane, an immobilized glucose oxidase (GOD) membrane, and a biocompatible membrane with diffusion-limiting effect were coated successively onto the working electrode. The sensor showed a rapid response (< 120 s in batch operation), good reproducibility (RE < 3%), good stability (over 36 h in control serum), a wide dynamic range (5-600 mg/dL glucose), and superior biocompatibility. It was used to determine glucose in serum. The data obtained from the sensor showed good agreement with that from a clinical autoanalyzer (R > 0.95).

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Biocompatible Materials Biosensing Techniques Blood Glucose Calibration Carbon Electrodes Hydrogen-Ion Concentration Membrane Potentials Membranes, Artificial Metals Needles Platinum Polymers Reproducibility of Results Temperature Journal Article

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C Y Chen, E Tamiya, K Ishihara, Y Kosugi, Y C Su, N Nakabayashi, I Karube. 1992. A biocompatible needle-type glucose sensor based on platinum-electroplated carbon electrode.. https://doi.org/10.1007/bf02921780

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