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Variable-ionic strength kinetic experiments in drug stability studies.

Giuseppe Alibrandi·Salvatore Coppolino·Santi D'Aliberti·Paola Ficarra·Norberto Micali·Antonino Villari
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Abstract

The dependence of the pseudo-first-order rate constant on the ionic strength for the alkaline hydrolysis of indomethacin has been obtained, for the first time, in a single kinetic experiment carried out by varying with time the salt concentration inside the reaction vessel. The kinetic profile obtained was processed using as a mathematical model the variable-parameter kinetic equation containing the Bronsted-Bjerrum equation as the dependence function. The results are in good agreement with those obtained by the traditional method but the experimental time is reduced to about one-tenth.

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Drug StabilityHydrogen-Ion ConcentrationHydrolysisIndomethacinModels, ChemicalOsmolar ConcentrationJournal ArticleResearch Support, Non-U.S. Gov't

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Giuseppe Alibrandi, Salvatore Coppolino, Santi D'Aliberti, Paola Ficarra, Norberto Micali, Antonino Villari. 2003. Variable-ionic strength kinetic experiments in drug stability studies.. https://doi.org/10.1002/jps.10422

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