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Gremlin - a putative pathogenic player in progressive renal disease.

Vincent Dolan·Madeline Murphy·Pilar Alarcon·Hugh R Brady·Carmel Hensey
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Abstract

Progressive renal fibrosis is the end process of renal injury leading to kidney failure. Current therapies for chronic renal failure aim to slow this process but fail to halt its progression. As the mechanisms involved in glomerulosclerosis and tubulointerstitial fibrosis are unravelled, potential treatments for this growing clinical problem should emerge. Gremlin, a developmental regulator of bone morphogenetic proteins (BMPs), has recently been implicated in processes such as glomerulosclerosis, tubulointerstitial fibrosis and cellular hypertrophy, and may represent a novel therapeutic target in progressive renal diseases.

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AnimalsBone Morphogenetic ProteinsDiabetes Mellitus, ExperimentalDiabetic NephropathiesDimerizationDisease ProgressionFeedback, PhysiologicalFibrosisGene Expression RegulationGlomerulosclerosis, Focal SegmentalHedgehog ProteinsHumansHypertrophyIntercellular Signaling Peptides and ProteinsKidney DiseasesKidney Failure, ChronicKidney GlomerulusMiceMice, KnockoutNephritis, InterstitialRatsTrans-ActivatorsJournal ArticleReview

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Vincent Dolan, Madeline Murphy, Pilar Alarcon, Hugh R Brady, Carmel Hensey. 2003. Gremlin - a putative pathogenic player in progressive renal disease.. https://doi.org/10.1517/14728222.7.4.523

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