[Immunohistochemical study on central nervous system cavernous hemangiomas].

Yao Zhao; Ying Mao; Liang-fu Zhou; Yu-lin Zhang

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PubMed · 12887740

[Immunohistochemical study on central nervous system cavernous hemangiomas].

Yao Zhao·Ying Mao·Liang-fu Zhou·Yu-lin Zhang

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Abstract

OBJECTIVE: To explore the histological structure, angiogenesis, and proliferative activity of central nervous system cavernous hemangiomas. METHODS: 70 surgical samples of central nervous system cavernous hemangiomas and 20 normal brain vessel samples from patients of epilepsy and open craniocerebral trauma were stained immunohistochemically with CD34, a-SMA; VEGF, Flt-1; and TGFa, Ki67 respectively. A comparison analysis was made according to the expression intensity. RESULTS: CD34 and a-SMA were expressed in all the normal control brain vessel tissues in a manner of obvious and continuous staining. VEGF, Flt-1 and TGFa were not expressed obviously in the normal brain tissues. 47 and 50 out of the 70 cavernous hemangioma specimens were positively stained for CD34 and a-SMA respectively, and their expression was less continuous. 68 and 44 out of the 70 cavernous hemangioma specimens were positively stained for VEGF and Flt-1 respectively with diffuse distribution. 68 cavernous hemangioma specimens were positively stained for TGF-a. A significant difference in expression intensity was found for the above 5 factors between the normal control brain tissue and cavernous hemangiomas (all P < 0.05). No expression of Ki67 was detected in all samples. CONCLUSION: The biological characteristics of cavernous hemangiomas are mainly relevant to the immaturity of the vessel wall. A series of angiogenic factors play an important role in the development of the lesion. The proliferative activity of the cavernous hemangiomas needs to be studied further.

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Actins Antigens, CD34 Brain Neoplasms Endothelial Growth Factors Extracellular Matrix Proteins Hemangioma, Cavernous Humans Immunohistochemistry Intercellular Signaling Peptides and Proteins Ki-67 Antigen Lymphokines Transforming Growth Factor alpha Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factors English Abstract Journal Article Research Support, Non-U.S. Gov't

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Yao Zhao, Ying Mao, Liang-fu Zhou, Yu-lin Zhang. 2003-04-10. [Immunohistochemical study on central nervous system cavernous hemangiomas].. https://pubmed.ncbi.nlm.nih.gov/12887740/

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