Does neurofilament phosphorylation regulate axonal transport?

Thomas B Shea; Cheolwha Jung; Harish C Pant

doi:10.1016/s0166-2236(03)00199-1

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Does neurofilament phosphorylation regulate axonal transport?

Thomas B Shea·Cheolwha Jung·Harish C Pant

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Abstract

Phosphorylation of neurofilaments has long been considered to regulate their axonal transport rate and, in doing so, to provide stability to mature axons. Interpretation of data recently obtained following C-terminal deletion experiments has prompted a challenge to this hypothesis. We present evidence that these deletion studies remain consistent with, rather than refute, a role for C-terminal phosphorylation in regulation of neurofilament axonal transport.

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Amino Acid Sequence Animals Axonal Transport Enzyme Inhibitors Mice Neurofilament Proteins Neurons Phosphoric Monoester Hydrolases Phosphorylation Protein Subunits Sequence Deletion Journal Article Review

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Thomas B Shea, Cheolwha Jung, Harish C Pant. 2003. Does neurofilament phosphorylation regulate axonal transport?. https://doi.org/10.1016/s0166-2236(03)00199-1

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