Persistent activity and memory in the entorhinal cortex.

Loren M Frank; Emery N Brown

doi:10.1016/s0166-2236(03)00176-0

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Persistent activity and memory in the entorhinal cortex.

Loren M Frank·Emery N Brown

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Abstract

The entorhinal cortex (EC) is an essential component of the medial temporal lobe long-term-memory system. Recently, Egorov et al. demonstrated that neurons in layer 5 of the EC show graded persistent activity: each neuron could maintain a constant rate firing over several minutes, even in the absence of input from other neurons. These findings suggest that layer-5 EC neurons could play a central role in the formation of associations among stimuli that occur at different times.

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Loren M Frank, Emery N Brown. 2003. Persistent activity and memory in the entorhinal cortex.. https://doi.org/10.1016/s0166-2236(03)00176-0

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