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Histone deacetylases.

Paul A Marks·Thomas Miller·Victoria M Richon
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Abstract

Post-translational modification of the histones of chromatin has a fundamental role in regulating gene expression. Enzymes involved in these epigenetic events include histone deacetylases (class I and class II), which can be inhibited by a structurally diverse group of small molecules. These histone deacetylase inhibitors induce growth arrest, differentiation and/or apoptosis of cancer cells in vitro and in vivo. Results of clinical trials with several of these agents have indicated that they are well tolerated at doses that have anti-tumour activity.

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AnimalsAntineoplastic AgentsClinical Trials as TopicDrug DesignEnzyme InhibitorsGene Expression Regulation, NeoplasticHistone Deacetylase InhibitorsHumansNeoplasmsStructure-Activity RelationshipJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Paul A Marks, Thomas Miller, Victoria M Richon. 2003. Histone deacetylases.. https://doi.org/10.1016/s1471-4892(03)00084-5

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