Microvascular function regulates intestinal crypt response to radiation.

Jerzy G Maj; François Paris; Adriana Haimovitz-Friedman; Ennapadam Venkatraman; Richard Kolesnick; Zvi Fuks

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PubMed · 12907601

Microvascular function regulates intestinal crypt response to radiation.

Jerzy G Maj·François Paris·Adriana Haimovitz-Friedman·Ennapadam Venkatraman·Richard Kolesnick·Zvi Fuks

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Abstract

Recent evidence suggests that microvascular endothelial apoptosis represents the primary lesion in radiation damage to the gastrointestinal (GI) tract. Rescue of endothelium by depletion of acid sphingomyelinase or i.v. treatment with basic fibroblast growth factor (FGF) prevented the lethal GI syndrome in C(57)Bl/6 mice. Here we show that basic FGF increased crypt survival after irradiation by 2-3 fold, with a dose modification factor at D(10) of 1.15 (P < 0.01). Basic FGF inhibited initial crypt damage, assessed by crypt shrinkage at 18-24 h, but did not significantly affect the regeneration of surviving crypts at 3.5 days after irradiation. These data suggest that microvascular function regulates expression of radiation-induced crypt stem cell clonogen damage in the evolution of radiation injury to the GI mucosa.

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Animals Endothelium, Vascular Fibroblast Growth Factor 2 Intestinal Mucosa Jejunum Male Mice Mice, Inbred C57BL Journal Article

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Jerzy G Maj, François Paris, Adriana Haimovitz-Friedman, Ennapadam Venkatraman, Richard Kolesnick, Zvi Fuks. 2003-08-01. Microvascular function regulates intestinal crypt response to radiation.. https://pubmed.ncbi.nlm.nih.gov/12907601/

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