In polymorphic genomic regions indels cluster with nucleotide polymorphism: Quantum Genomics.

Natalie Longman-Jacobsen; Joseph F Williamson; Roger L Dawkins; Silvana Gaudieri

doi:10.1016/s0378-1119(03)00621-8

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In polymorphic genomic regions indels cluster with nucleotide polymorphism: Quantum Genomics.

Natalie Longman-Jacobsen·Joseph F Williamson·Roger L Dawkins·Silvana Gaudieri

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Abstract

Previously, we have described polymorphic frozen blocks (PFBs) within the Major Histocompatibility Complex (MHC) as regions of several hundred kilobases characterised by high nucleotide diversity, little or no recombination, duplicated segments, disease susceptibility, and human endogenous retroviruses. The nucleotide diversity profile within these PFBs shows peaks and troughs outside of the Class I genes, reflecting other important genes (or sequences) in the region. Here we show that indel density is also clustered with similar peaks and troughs. In fact, SNPs and indels are co-located within PFBs.

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Databases, Nucleic Acid Gene Frequency Genetic Variation Genome, Human Humans Major Histocompatibility Complex Mutagenesis, Insertional Polymorphism, Single Nucleotide Sequence Deletion Journal Article Research Support, Non-U.S. Gov't

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Natalie Longman-Jacobsen, Joseph F Williamson, Roger L Dawkins, Silvana Gaudieri. 2003-07-17. In polymorphic genomic regions indels cluster with nucleotide polymorphism: Quantum Genomics.. https://doi.org/10.1016/s0378-1119(03)00621-8

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