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Decrease of hemostatic cardiovascular risk factors by aggressive vs. conventional atorvastatin treatment in patients with Type 2 diabetes mellitus.

M A Van De Ree·M P M De Maat·C Kluft·A E Meinders·H M G Princen·M V Huisman·DALI Study Group
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Abstract

BACKGROUND: Patients with Type 2 diabetes mellitus have increased levels of hemostatic risk variables for cardiovascular disease, such as fibrinogen, von Willebrand factor (VWF), factor (F)VIIa, d-dimer and plasminogen activator inhibitor-1 (PAI-1). OBJECTIVES: To evaluate the effect of aggressive vs. standard dose atorvastatin on hemostatic cardiovascular risk factors in patients with Type 2 diabetes mellitus. PATIENTS AND METHODS: The effect of 30 weeks of treatment with atorvastatin 10 and 80 mg on hemostatic cardiovascular risk factors was assessed in a randomized double-blind placebo-controlled trial on 217 patients with Type 2 diabetes mellitus and dyslipidemia. RESULTS AND CONCLUSIONS: Atorvastatin 10 and 80 mg dose-dependently reduced d-dimer (7.4% and 8.5%, respectively, P for trend = 0.004) and PAI-1 antigen levels (9.0% and 18%, respectively, P for trend = 0.021). Levels of fibrinogen, VWF, tissue-type plasminogen activator and FVIIa were not influenced by atorvastatin. In conclusion, in patients with Type 2 diabetes mellitus, atorvastatin dose-dependently improved the levels of the hemostatic risk variables d-dimer and PAI-1.

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AgedAtorvastatinCardiovascular DiseasesDiabetes Mellitus, Type 2Dose-Response Relationship, DrugDouble-Blind MethodFactor VIIIaFemaleFibrinogenHemostaticsHeptanoic AcidsHumansHyperlipidemiasMaleMiddle AgedPlacebosPyrrolesRisk FactorsTime FactorsTissue Plasminogen Activatorvon Willebrand FactorClinical TrialJournal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov't

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M A Van De Ree, M P M De Maat, C Kluft, A E Meinders, H M G Princen, M V Huisman, DALI Study Group. 2003. Decrease of hemostatic cardiovascular risk factors by aggressive vs. conventional atorvastatin treatment in patients with Type 2 diabetes mellitus.. https://doi.org/10.1046/j.1538-7836.2003.00357.x

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