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Long-range DNA charge transport.

Sarah Delaney·Jacqueline K Barton
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Abstract

The stack of base pairs within double helical DNA has been shown to mediate charge transport reactions. Charge transport through DNA can result in chemistry at a distance, yielding oxidative DNA damage at a site remote from the bound oxidant. Since DNA charge transport chemistry depends on coupling within the stacked base pair array, this chemistry is remarkably sensitive to sequence-dependent DNA structure and dynamics. Here, we discuss different features of DNA charge transport chemistry, including applications as well as possible biological consequences and opportunities.

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DNADNA DamageModels, MolecularNucleic Acid ConformationJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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Sarah Delaney, Jacqueline K Barton. 2003-08-22. Long-range DNA charge transport.. https://doi.org/10.1021/jo030095y

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