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PubMed · 12921396

Probability models and computational models for ANOVA in multicenter clinical trials.

Thomas Permutt
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Abstract

Multicenter trials are usually analyzed by fixed-effects, two-way analysis of variance. A mixed-effects computation with random treatment-by-center interaction may produce better results even if this interaction is considered truly to be a fixed effect. It may be more appropriate, however, to consider the treatment-by-center interaction to be a random effect, anyway.

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Analysis of VarianceMathematical ComputingModels, StatisticalMulticenter Studies as TopicJournal Article

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Thomas Permutt. 2003. Probability models and computational models for ANOVA in multicenter clinical trials.. https://doi.org/10.1081/bip-120022769

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