Molecular diversity through sugar scaffolds.

Giang Thanh Le; Giovanni Abbenante; Bernd Becker; Matthias Grathwohl; Judy Halliday; Gerry Tometzki; Johannes Zuegg; Wim Meutermans

doi:10.1016/s1359-6446(03)02751-x

PubMed · 12927513

Molecular diversity through sugar scaffolds.

Giang Thanh Le·Giovanni Abbenante·Bernd Becker·Matthias Grathwohl·Judy Halliday·Gerry Tometzki·Johannes Zuegg·Wim Meutermans

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Abstract

Monosaccharides provide an excellent platform to tailor molecular diversity by appending desired substituents at selected positions around the sugar scaffold. The presence of five functionalized and stereo-controlled centres on the sugar scaffolds gives the chemist plenty of scope to custom design molecules to a pharmacophore model. This review focuses on the peptidomimetic developments in this area, as well as the concept of tailoring structural and functional diversity in a library using carbohydrate scaffolds and how this can lead to increased hit rates and rapid identification of leads, which has promising prospects for drug development.

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Animals Carbohydrates Combinatorial Chemistry Techniques Humans Molecular Conformation Molecular Structure Stereoisomerism Journal Article Review

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Giang Thanh Le, Giovanni Abbenante, Bernd Becker, Matthias Grathwohl, Judy Halliday, Gerry Tometzki, Johannes Zuegg, Wim Meutermans. 2003-08-01. Molecular diversity through sugar scaffolds.. https://doi.org/10.1016/s1359-6446(03)02751-x

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