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Finding genes for SLE: complex interactions and complex populations.

Marta E Alarcón-Riquelme·Ludmila Prokunina
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Abstract

Many years of work, multiplex family collection and endless genotyping finally give fruit. The original aim cannot be lost. The aim is not only to identify mutations involved in susceptibility for systemic lupus erythematosus (SLE) but to elucidate the disease pathogenesis as well. After genetics comes the biology. We review our recent findings on the genetics of lupus, provide possible mechanisms for disease susceptibility and present some facts on the problematic of identifying susceptibility mutations for complex diseases in complex human populations.

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Antigens, CDAntigens, SurfaceApoptosis Regulatory ProteinsCore Binding Factor Alpha 2 SubunitDNA-Binding ProteinsEnhancer Elements, GeneticGenetic Predisposition to DiseaseGenetics, PopulationHumansLupus Erythematosus, SystemicProgrammed Cell Death 1 ReceptorProto-Oncogene ProteinsTranscription FactorsJournal ArticleReview

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Marta E Alarcón-Riquelme, Ludmila Prokunina. 2003. Finding genes for SLE: complex interactions and complex populations.. https://doi.org/10.1016/s0896-8411(03)00093-3

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