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PubMed · 12956055

Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors.

Emma Vickerstaffe·Brian H Warrington·Mark Ladlow·Steven V Ley
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Abstract

The first fully automated multi-step polymer assisted solution phase (PASP) synthesis is described. An array of histone deacetylase (HDAc) inhibitors was prepared by an unattended 4-5 step sequence incorporating in-line 'catch and release' purification.

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AutomationCatalysisCombinatorial Chemistry TechniquesEnzyme InhibitorsHistone Deacetylase InhibitorsHydroxamic AcidsPalladiumPolymersJournal ArticleResearch Support, Non-U.S. Gov't

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Emma Vickerstaffe, Brian H Warrington, Mark Ladlow, Steven V Ley. 2003-07-21. Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors.. https://doi.org/10.1039/b305713e

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