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Engineered microsphere contrast agents for optical coherence tomography.

Tin Man Lee·Amy L Oldenburg·Shoeb Sitafalwalla·Daniel L Marks·Wei Luo·Farah Jean-Jacques Toublan·Kenneth S Suslick·Stephen A Boppart
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Abstract

Contrast agents are utilized in virtually every imaging modality to enhance diagnostic capabilities. We introduce a novel class of optical contrast agent, namely, encapsulating microspheres, that are based not on fluorescence but on scattering nanoparticles within the shell or core. The agents are suitable for reflection- or scattering-based techniques such as optical coherence tomography, light microscopy, and reflectance confocal microscopy. We characterize the optical properties of gold-, melanin-, and carbon-shelled contrast agents and demonstrate enhancement of optical coherence tomography imaging after intravenous injection of such an agent into a mouse.

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AnimalsContrast MediaLiverMaleMiceMicrospheresNanotechnologyOptics and PhotonicsTomographyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Tin Man Lee, Amy L Oldenburg, Shoeb Sitafalwalla, Daniel L Marks, Wei Luo, Farah Jean-Jacques Toublan, Kenneth S Suslick, Stephen A Boppart. 2003-09-01. Engineered microsphere contrast agents for optical coherence tomography.. https://doi.org/10.1364/ol.28.001546

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