PubMed · 1295908
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P Testas. 1992. [Celioscopic digestive surgery].. https://pubmed.ncbi.nlm.nih.gov/1295908/
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The author commemorating professor Géza Hetényi, discusses the relation of endoscopy and x-ray diagnostic. He observes that the spreading of recent fibre optical endoscopes did not solve the problem of the early gastric cancer diagnosis. The experiences of the author based on his practice for several decades, data from the literature and, especially, the Japanese results show that x-ray did not lose its position but rather strengthened it in the diagnostics of the upper gastrointestinal tract. For examinations at identical levels, both diagnostic methods have equal opportunities to reveal gastric cancer at an early stage. In accordance with the type variety of early gastric cancer, the author discusses the relationship between early gastric cancer and gastric ulcer, and he proposes a rational algorithm for its diagnosis and follow-up. He shows that the most effective method for the diagnosis of the upper gastrointestinal tract is a reasonable combination of all available methods, and "primus inter pares" of them is x-ray examination, in addition to endoscopy.
Between 1980 and 1991, 96 patients with documented polycythemia vera were treated by hydroxyurea or pipobroman, according to a protocol including randomization, and maintenance therapy. Complete remission was induced in all cases. Two cases treated with hydroxy-urea had a very severe granulothrombocytopenia during the initial phase. Maintenance was generally satisfactory on pipobroman, but the platelet count often remained high (400 to 900.10(9)/l) on low-dosage hydroxy-urea, with a risk of vascular events. Progressive resistance to these drugs was observed in 5 cases. Digestive and cutaneous troubles were more frequent on pipobroman maintenance, sometimes enough to legitimate a therapeutic change. It may be concluded that such a treatment is less easy to use and to follow than is currently accepted. In the present series (397/years/patients follow-up, median 5-3 years), only one leukemia and one cancer were observed, which however only demonstrates the absence of any carcinogenic risk at short- but not at long-term.
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