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PubMed · 12959352

Immunotherapy with anti-CD20 compounds.

Christoph von Schilling
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Abstract

The B-cell surface antigen CD20 is currently the prime target for near-selective treatment of mature B-cell malignancies and a range of reactive B-cell associated disorders (including virus-associated lymphoproliferation or autoimmune conditions). CD20 is strongly and homogeneously expressed on the majority of mature B-cell neoplasms except chronic lymphocytic leukaemia cells, and on all mature reactive B-cells. This review will summarise the modes of action of various reagents targeting CD20. Treatment results following their use in single and combination therapy for B-cell disorders are reviewed.

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AnimalsAntibodies, MonoclonalAntibodies, Monoclonal, Murine-DerivedAntigens, CD20Antineoplastic AgentsClinical Trials as TopicCombined Modality TherapyHumansImmunotherapyLeukemia, B-CellLymphoma, B-CellRituximabJournal ArticleReview

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Christoph von Schilling. 2003. Immunotherapy with anti-CD20 compounds.. https://doi.org/10.1016/s1044-579x(03)00018-x

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