Enhanced release from proactive interference in nonamnesic alcoholic individuals: implications for impaired associative binding.

Eve De Rosa; Edith V Sullivan

doi:10.1037/0894-4105.17.3.469

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Enhanced release from proactive interference in nonamnesic alcoholic individuals: implications for impaired associative binding.

Eve De Rosa·Edith V Sullivan

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Abstract

Proactive interference (PI) occurs when previously learned information reduces the ability to acquire new, related information. Given that PI is modulated by the cholinergic system in rats (E. De Rosa & M. E. Hasselmo, 2000) and that chronic alcohol dependence disrupts cholinergic function in rats and humans, associative properties of PI in patients with alcoholism were examined. It was hypothesized that normal PI contingencies would be disrupted in alcoholic participants. When tested with a paired-associate simultaneous discrimination paradigm, analogous to that used in the rat model, alcoholic participants showed significantly less PI than controls yet performed comparably on a control response reversal task. The absence of PI in alcoholic participants may reflect impaired configural binding of paired-associate stimuli while sparing the elemental ability to process each stimulus component.

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Acetylcholine Adult Alcoholism Association Learning Case-Control Studies Color Perception Discrimination Learning Humans Male Middle Aged Neuropsychological Tests Proactive Inhibition Prosencephalon Psychomotor Performance Journal Article Research Support, U.S. Gov't, P.H.S.

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Eve De Rosa, Edith V Sullivan. 2003. Enhanced release from proactive interference in nonamnesic alcoholic individuals: implications for impaired associative binding.. https://doi.org/10.1037/0894-4105.17.3.469

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