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[Improved method of epalrestat synthesis].

Rong Sheng·Tao Liu·Yong-zhou Hu
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Abstract

OBJECTIVE: To synthesize epalrestat and to improve the method of synthesis. METHODS: Glycine reacted with carbondisulfide,then with ClCH(2)COONa to give 3-carboxymethylrhodanine. PhCHO reacted with CH(3)CH(2)CHO in NaOH/EtOH solution to produce 2-methylcinnamaldehyde.3-carboxymethylrhodanine and 2-methylcinnamaldehyde were treated with NH(3).H(2)O to obtain epalrestat. RESULT: The described method was effective in synthesis of Epalrestat and the yield was higher than that of in references. CONCLUSION: The results suggest that this method is suitable for industrial production.

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Aldehyde ReductaseEnzyme InhibitorsRhodanineThiazolidinesEnglish AbstractJournal Article

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Rong Sheng, Tao Liu, Yong-zhou Hu. 2003. [Improved method of epalrestat synthesis].. https://doi.org/10.3785/j.issn.1008-9292.2003.04.022

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