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Alpha-synuclein: between synaptic function and dysfunction.

G Di Rosa·D Puzzo·A Sant'Angelo·F Trinchese·O Arancio
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Abstract

Alpha-synuclein belongs to a family of vertebrate proteins, encoded by three different genes: alpha, ss, and gamma. The protein has become of interest to the neuroscience community in the last few years after the discovery that a mutation in the alpha-synuclein gene is associated with familial autosomal-dominant early-onset forms of Parkinson Disease. However, it is not yet clear how the protein is involved in the disease. Several studies have suggested that alpha-synuclein plays a role in neurotransmitter release and synaptic plasticity. This hypothesis might help elucidate how alpha-synuclein malfunctioning contributes to the development of a series of disorders known as synucleinopathies.

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AnimalsEnvironmentHumansMutationNerve Tissue ProteinsNeurodegenerative DiseasesParkinson DiseaseSynapsesSynaptic TransmissionSynucleinsUbiquinoneUbiquitin-Protein Ligasesalpha-SynucleinJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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G Di Rosa, D Puzzo, A Sant'Angelo, F Trinchese, O Arancio. 2003. Alpha-synuclein: between synaptic function and dysfunction.. https://doi.org/10.14670/hh-18.1257

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