PubMed2003
The processes of organization and fibrosing were investigated in the tuberculosis-involved and non tuberculosis-involved lung tissue of the lungs and their parts resected in 307 patients with different forms of tuberculosis by histological, histochemical, luminescence microscopic, biochemical, and morphometric studies. When tuberculous lesions develop and begin fibrosing, there was impairment of final formation of collagenous fibers in their inner area due the low proliferative capacity of epithelioid and giant cells, shortage of fibrogenic cells and precipitation on the argyrophilic fibrillary network of tissue degradation products. Etiologically, pathogenetically, and histogenetically, the development of tuberculous lesions gives rise to posttuberculous fibrosis while that of extratuberculosis lesions leads to metatuberculous fibrosis due to the modification and coarsening of preformed connective tissue. The formation of fibrosis is caused by a combination of definite factors: clinicomorphological forms of tuberculosis, long-term history of the disease, the extent of lung tissue decay, old age, the pattern of antituberculous treatment (regular or regular), the extent of the impaired capillary network, the type of arbitrarily fibrogenic cells functioning inside and outside the area of inflammation.