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PubMed · 12974801

HLA-B27 polymorphism in the Malays.

Abstract

The frequency of HLA-B27 and its subtypes was determined in 878 Malay subjects. Thirty-five of the subjects typed for HLA-A, -B and -DR were found to be positive for HLA-B27. The frequency of this allele in the Malay population was found to be 3.99%. The subtypes observed and their frequencies are: HLA-B*2704 (19.4%), HLA-B*2705 (5.6%), HLA-B*2706 (72.2%) and HLA-B*2707 (2.8%).

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BibTeXRIS

J S Dhaliwal, C L Too, M Lisut, Y Y Lee, S Murad. 2003. HLA-B27 polymorphism in the Malays.. https://doi.org/10.1034/j.1399-0039.2003.00107.x

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[HLA-B27 polymorphism and spondyloarthropathies].

The association of HLA-B27 with ankylosing spondylitis (AS), and other spondyloarthropathies (SpA), remains as one of the strongest between HLA molecules and human disease. Since it was reported, in 1973, it has been extensively studied in order to understand the underlying pathogenic mechanism. The objective of this article is to review the current knowledge on the structure and polymorphism of HLA-B27 molecule, as well as describe the main pathogenic hypotheses trying to explain its association with AS.

HLA-B27 Antigen↗