Long-range correlations in nucleotide sequences.

C K Peng; S V Buldyrev; A L Goldberger; S Havlin; F Sciortino; M Simons; H E Stanley

doi:10.1038/356168a0

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Long-range correlations in nucleotide sequences.

C K Peng·S V Buldyrev·A L Goldberger·S Havlin·F Sciortino·M Simons·H E Stanley

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Abstract

DNA sequences have been analysed using models, such as an n-step Markov chain, that incorporate the possibility of short-range nucleotide correlations. We propose here a method for studying the stochastic properties of nucleotide sequences by constructing a 1:1 map of the nucleotide sequence onto a walk, which we term a 'DNA walk'. We then use the mapping to provide a quantitative measure of the correlation between nucleotides over long distances along the DNA chain. Thus we uncover in the nucleotide sequence a remarkably long-range power law correlation that implies a new scale-invariant property of DNA. We find such long-range correlations in intron-containing genes and in nontranscribed regulatory DNA sequences, but not in complementary DNA sequences or intron-less genes.

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Animals Base Sequence DNA Humans Introns Nucleotide Mapping Regulatory Sequences, Nucleic Acid Statistics as Topic NASA Discipline Cardiopulmonary Non-NASA Center Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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C K Peng, S V Buldyrev, A L Goldberger, S Havlin, F Sciortino, M Simons, H E Stanley. 1992-03-12. Long-range correlations in nucleotide sequences.. https://doi.org/10.1038/356168a0

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