PubMed · 13018965
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J LEZOVIC. 1952. Sarcoma gingiva.. https://pubmed.ncbi.nlm.nih.gov/13018965/
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Hepatocyte growth factor (HGF) was discovered as a potent mitogen for adult hepatocytes from the plasma of patients with fulminant hepatic failure. It is now known to be a broad-spectrum, multi-functional mitogen, motogen and morphogen. The activities of HGF are mediated through the signalling pathway of its receptor, c-Met. During tooth development, HGF is expressed in the dental papilla and c-Met is expressed in the inner enamel epithelium. The expression of HGF and c-Met indicates that HGF is involved in morphogenesis of the tooth by mediating epithelial-mesenchymal interactions. In the mature tooth, HGF expression by fibroblasts is enhanced in pulpitis and mediated through the induction of prostaglandin (PG) E(2); it is induced not only by inflammatory cytokines, but also by components of oral bacteria. Consequently, concentrations of HGF in gingival crevicular fluid (GCF) increase in periodontitis. The mitogenic and other biological activities, such as angiogenesis, of HGF contribute towards wound healing. Both HGF and c-Met are expressed in the developing tongue, and the signalling pathway of the latter is shown to be essential for myogenesis. Dysregulation of c-Met signalling is observed in carcinogenesis, but HGF also has cytotoxic activity to certain tumour cells. The reason for the discrepancy between these observations is not clear at present.
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The free gingival graft is one of the most versatile and predictable procedures in current use. A review of the significant contributions leading to this procedure is presented. Reports of the free graft series of King and Pennel, as well as the reaction to its initial presentation by members of the Philadelphia Society of Periodontology, are introduced to the dental literature. The chronology of events leading to the rediscovery of the gingival graft procedure in the early 1960s suggests independent and nearly simultaneous clinical innovation took place in Sweden and the United States. Therefore, though fully acknowledging Hilding Björn's seminal contribution, substantial credit must be given to colleagues King and Pennel for introducing the gingival graft procedure to periodontics.