PubMed · 13112708
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1953. [Anatomicopathologic conferences: Case No. 1].. https://pubmed.ncbi.nlm.nih.gov/13112708/
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The authors report a patient with recurrent lumbosacral myxopapillary ependymoma, followed for more than 20 years, who presented with severe axial pain resulting from osteolytic destruction at the lumbosacral junction. Because the patient had a long history of paraplegia despite three previous incomplete tumor resections, we chose not to attempt a fourth resection. Moreover, because viable fixation points were not present within the sacrum and most of the lumbar spine, instrumented fusion was extended from T7 to the ilia using a modified Galveston L-rod technique, which we believe to be unique in its application to this problem. This case demonstrates the long-term potential for instability from locally destructive myxopapillary ependymoma that is incompletely excised. We are not aware of any previous reports of lumbopelvic instability in association with myxopapillary ependymomas.
The authors report a case of clear cell ependymoma with a lipidized component that developed in the thoracic spinal cord. A 59-year-old man was admitted to the hospital with an itchy pain in the left forearm to the left anterior and lateral chest for the past three years. Neurological findings on admission included dissociated sensory disturbance below the C8 level and increased deep tendon reflex in both lower extremities. An MRI scan of the spinal cord revealed an intramedullary tumor with a longer diameter of 3.5 cm at the T3-T4 level and a distended syrinx at the T2-T3 level. Surgery was performed after T1-T5 laminectomy. The gray, soft and well demarcated tumor was removed subtotally. Light microscopy revealed a portion where clear cells proliferated and a portion where foamy cells proliferated. In some tissue, there were a very few nuclear areas suggestive of a perivascular pseudorosette. Neither nuclear division nor necrosis was observed. Immunohistochemically, the tumor cells were positive for glial fibrillary acidic protein (GFAP), epithelial membrane antigen (EMA), vimentin, and negative for cytokeratin, synaptophysin. The MIB-1 staining index was 0.25%. Based on these findings, diagnosis of clear cell ependymoma with a lipidized component was made.
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