Thrombomodulin, an endothelial anticoagulant; its structure, function and expression.

I Maruyama

doi:10.1253/jcj.56.187

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Thrombomodulin, an endothelial anticoagulant; its structure, function and expression.

I Maruyama

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Abstract

Thrombomodulin is an endothelium-associated glycoprotein that converts thrombin from a procoagulant protease to an anticoagulant. Thrombin, a key enzyme in thrombus formation, binds to thrombomodulin on the endothelium. However after thrombin binds to thrombomodulin, it fails to act on the coagulation factors and platelets, and its ability to activate protein C is enhanced more than 1,000-fold. This article reviews the recent progress in the study of thrombomodulin.

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Blood Coagulation Endothelium, Vascular Humans Molecular Structure Protein C Receptors, Cell Surface Receptors, Thrombin Thrombin Thrombosis Journal Article Review

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I Maruyama. 1992. Thrombomodulin, an endothelial anticoagulant; its structure, function and expression.. https://doi.org/10.1253/jcj.56.187

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