PubMed · 13140567
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F TINACCI. 1953. [Cellular degenerative processes from malonate administration].. https://pubmed.ncbi.nlm.nih.gov/13140567/
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The branched building plays a pivotal part in the study of Dendrimers. In order to synthesized Dendrimers more effectively, we designed and synthesized four new branched building blocks via 2-4 steps starting from diethyl malonate and pentaerythritol. Their structures were confirmed by IR and 1HNMR etc. They compare favourably with previous branched building blocks as regards to steric hindrance and branched effect.
2-Substituted malonamide derivatives were synthesized and tested for cholecystokinin A (CCK-A) receptor inhibitory activity. Significant CCK-A receptor inhibitory activities were found in only three compounds (4g-i) which have carboxyl group. In order to study structure-activity relationships, carboxyethyl group was selected for 2-substituent and a number of N-substituted malonamides were prepared. After these compounds were tested for CCK-A receptor inhibitory activity, 4-(3,4-dichlorophenylcarbamoyl)-N,N-dipentylglutaramic acid (4h) was selected as the most preferred compound.
It has been found that malonic dialdehyde penetrates through the filters of cigarettes. The filter cigarettes, such as "Club", "F6", "Cabinet", "Semper" and "Kenton" as well as non-filter cigarettes, namely "Salem", "Real" and "Karo" generate malonic dialdehyde during smoking, in amounts ranging from 15.6 to 44.3 mg/kg, i.e. from 20.4 to 44.3 mg/kg for cigarettes with filters and from 15.6 to 27.1 mg/kg for non-filter cigarettes.