PubMed · 13172484
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F N POYNTER. 1954-07-10. Thomas Bowdler.. https://doi.org/10.1136/bmj.2.4879.97
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Oxygen is the most commonly used 'drug' in neonatal units as an integral part of respiratory support. It has also been known for half of the century that it is easy to damage the eyes of preterm infants by giving too much oxygen especially in the first few weeks of life. Despite this knowledge there is still a wide variation in approaches to oxygen monitoring within neonatal units. A randomized controlled trial conducted more than 50 years ago first made clinicians aware of 'oxygen toxicity' in preterm infants, but no other controlled trial has ever been conducted since to clarify how much oxygen infants really need, or what oxygen saturation level is optimal in caring these preterm babies. Perhaps time has come for clinicians to resolve this 'uncertainty' by well-designed randomized trials.
The first recognition of the profession of occupational hygienist was preceded by at least 200 years of developments in disease prevention practices in the workplace, many of which could readily be characterized as occupational hygiene. The nature and pace of adoption of these practices depended on the contemporary state of technology, science, medicine and social concern. At first it was a matter of individual initiative and did not depend on quantitative data, but by the second half of the 19th century techniques of measurement for both harmful effects and for exposure were being introduced and official bodies at both national and local level were active. People from a wide range of backgrounds made contributions to disease prevention at work and by 1920 most of the major concepts and practices of current occupational hygiene practice were in place, if only in rather limited settings.
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