PubMed · 13180280
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A M LORENTZ DE HAAS, S WATERMAN. 1954. [Abdominal epilepsy].. https://pubmed.ncbi.nlm.nih.gov/13180280/
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BACKGROUND: Extracranial metastases from meningioma are rare, and are reported to occur in less than 1 per 1000. CASE REPORT: We report a 54-year-old man, who presented with a parasagittal meningioma with skull erosion and overlying soft tissue invasion. Tumour invading the superior sagittal sinus was not removed, and postoperative radiation was therefore delivered to the excision site. Histology was consistent with an atypical meningioma. The patient had a re-operation of a recurrence 3.5 years later, and after another year six tumours were detected close to pleura and in the lungs. A biopsy from the largest one demonstrated a metastasis having the same histology as the primary tumour. CONCLUSION: Risk factors for metastasis of cerebral meningiomas have been suggested to be histological malignancy grade, venous sinus invasion, and local recurrences after previous craniotomy.
OBJECTIVES: To develop standardized definitions for classification of partial seizure symptoms for use in genetic research on the epilepsies, and evaluate inter-rater reliability of classifications based on these definitions. METHODS: The authors developed the Partial Seizure Symptom Definitions (PSSD), which include standardized definitions of 41 partial seizure symptoms within the sensory, autonomic, aphasic, psychic, and motor categories. Based on these definitions, two epileptologists independently classified partial seizures in 75 individuals from 34 families selected because one person had ictal auditory symptoms or aphasia. The data used for classification consisted of standardized diagnostic interviews with subjects and family informants, and medical records obtained from treating neurologists. Agreement was assessed by kappa. RESULTS: Agreement between the two neurologists using the PSSD was "substantial" or "almost perfect" for most symptom categories. CONCLUSIONS: Use of standardized definitions for classification of partial seizure symptoms such as those in the Partial Seizure Symptom Definitions should improve reliability and accuracy in future genetic studies of the epilepsies.
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