Mitotic checkpoints.

T Nishimoto; S Uzawa; R Schlegel

doi:10.1016/0955-0674(92)90029-c

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Mitotic checkpoints.

T Nishimoto·S Uzawa·R Schlegel

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Abstract

Entry into mitosis is triggered by activation of maturation promoting factor and a complex of p34cdc2 kinase and cyclin B. Activation induces nuclear lamina breakdown, chromosome condensation and mitotic spindle assembly. Exit from mitosis is initiated by the degradation of cyclin B and the subsequent inactivation of maturation-promoting factor. A more thorough understanding of the checkpoints for initiation of and exit from mitosis has evolved during the past few years.

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Animals Cyclins GTP Phosphohydrolases Humans Mitosis Models, Biological Phosphoric Monoester Hydrolases Protein Kinases Journal Article Review

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T Nishimoto, S Uzawa, R Schlegel. 1992. Mitotic checkpoints.. https://doi.org/10.1016/0955-0674(92)90029-c

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