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Cerebellar long-term potentiation under suppressed postsynaptic Ca2+ activity.

K Shibuki·D Okada
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Abstract

To study the roles of postsynaptic Ca2+ activity in cerebellar synaptic plasticity, we used a patch-recording technique in Purkinje cell dendrites. While the combination of parallel fibre stimulation and 8-bromo cyclic guanosine monophosphate (Br-cGMP) application produced long-term depression (LTD) of the parallel fibre/Purkinje cell transmission, the same stimuli evoked long-term potentiation (LTP) during postsynaptic injection of Ethyleneglycol-bis-(beta-amino-ethylether)-N, N, N', N'-tetraacetate (EGTA). Furthermore, in the presence of alpha-aminobutyric acid (GABA), parallel fibre stimulation plus Br-cGMP produced LTP of extracellular K+ increases following parallel fibre stimulation. These results suggest that postsynaptic Ca2+ activity in Purkinje cells is negatively correlated to the direction of plastic changes and that the Ca2+ changes and cGMP play distinct roles in cerebellar synaptic plasticity.

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AnimalsCalciumCerebellumCyclic GMPEvoked PotentialsMaleNeuronal PlasticityRatsRats, Inbred StrainsSynapsesTime FactorsJournal Article

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K Shibuki, D Okada. 1992. Cerebellar long-term potentiation under suppressed postsynaptic Ca2+ activity.. https://doi.org/10.1097/00001756-199203000-00003

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