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Transient decrease in rat striatal D2 dopamine receptor mRNA level after acute haloperidol treatment.

M Sakata·C Prasad
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Abstract

Acute haloperidol administration decreases the number of rat striatal D2 dopamine receptor (D2-receptor). The potential involvement of decreased D2-receptor gene transcription in the above process was examined using Northern blot analysis. There was a dose- and time-dependent transient decrement in the level of striatal D2-receptor mRNA after haloperidol. The decrease in transcription may be mediated via blockade of D2-receptor, since S(-)-sulpiride but not the inactive enantiomer R(+)-sulpiride produced the inhibition.

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AnimalsBlotting, NorthernCorpus StriatumDown-RegulationHaloperidolKineticsMaleRNA, MessengerRatsRats, WistarReceptors, Dopamine D2Time FactorsJournal Article

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M Sakata, C Prasad. 1992. Transient decrease in rat striatal D2 dopamine receptor mRNA level after acute haloperidol treatment.. https://doi.org/10.1016/0169-328x(92)90185-e

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