PubMed · 13319558
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H A ZANDER. 1956. A method for studying the epithelial attachment.. https://doi.org/10.1177/00220345560350022401
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OBJECTIVE: To investigate the expression of cytokeratins (CK) in the normal human gingival epithelium and to explore the difference between junctional epithelium (JE), oral epithelium (OE) and sulcular epithelium (SE). METHODS: Teeth specimens with gingival tissue were collected from 5 people. Paraffin-embedded sections were stained with monoclonal antibodies responded respectively to human CK5/6, 7, 8/18, 10/13, 16, 17, 19, 20. RESULTS: CK7 and 17 was not expressed in all strata of JE, OE and SE. CK5/6 and 20 were weekly or moderately expressed in the suprabasal, and not expressed in the basal layer of all three epithelia. CK10/13 and 16 were positive in all strata of JE and in the suprabasal layers of OE and SE. CK10/13 was moderately to strongly expressed and CK16 was weekly to moderately expressed. The staining for CK19 was intense in all strata of JE and the basal layer of OE and SE. There was a remarkable demarcation between JE and SE. The pattern of CK8/18 expression was similar to that of CK19, but was weaker. Besides the basal layer, some suprabasal layers close to the basal layer were stained. CONCLUSIONS: JE is an unique non-differentiated stratified epithelium different from OE and SE. CK19 would be a histological marker and CK10/13, 16 would be the cellular markers to differentiate JE from OE and SE.
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Biologic contributions to the smile play an important role in esthetics. The impact of the gingival complex on the esthetic qualities of a smile are significant, and both patients and dentists are developing a greater appreciation for the impact of gingiva on the beauty of a smile. Historically, the focus of periodontal therapy has been on managing patients with longer-appearing teeth secondary to attachment loss through pathology or as a result of periodontal surgery. Nevertheless, early diagnosis and treatment, as well as modern techniques and materials, have helped periodontology evolve to a point where such problems occur less frequently.