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PubMed · 1333315

Recurrent herpetic keratitis during topical acyclovir application.

J M Soriano·J Funk·P Janknecht·B Matz
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Abstract

Dendritic herpetic keratitis developed in a 49-year-old patient during topical acyclovir treatment. A positive herpes simplex culture was obtained. After acyclovir was replaced by trifluorothymidine and interferon, the dendritic lesion disappeared and herpes simplex culture became negative. Six months later a carcinoma of the larynx was diagnosed. The acyclovir-resistant herpetic keratitis may be associated with the carcinoma because resistant herpes simplex virus strains are predominantly described in patients suffering from immune deficiency.

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AcyclovirDrug Resistance, MicrobialHumansInterferon Type IInterferon-alphaKeratitis, HerpeticMaleMiddle AgedOphthalmic SolutionsRecombinant ProteinsRecurrenceSimplexvirusTrifluridineCase ReportsJournal Article

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J M Soriano, J Funk, P Janknecht, B Matz. Recurrent herpetic keratitis during topical acyclovir application.. https://doi.org/10.1177/112067219200200308

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