PubMed · 13333490
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C REQUESENS, J BONNIN, J N REQUEJO. 1956. [Primary osseous lymphosarcoma].. https://pubmed.ncbi.nlm.nih.gov/13333490/
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Atherosclerosis, nearly universally present in major arteries of Western adults, is characterized in all affected arteries by cholesterol-laden plaques and consistently associated with blood cholesterol levels. Other risk factors are reported to have relatively stronger or weaker associations with different atherosclerotic manifestations, but such differences have never previously been quantified. Measuring them may offer fresh clues to atherogenic processes and their prevention. The Atherosclerosis Risk in Communities Study (ARIC) ascertained incident coronary heart disease (CHD) and measured subclinical atherosclerosis as carotid artery intimal medial thickness using ultrasound and as lower extremity arterial disease (LEAD) using ankle-brachial blood pressure index. Blood cholesterol was associated with all endpoints. When standardized against LDL cholesterol associations, diabetes and smoking showed substantially different strengths of associations with different endpoints. Relative to associations with LDL cholesterol: (1) smoking, but not diabetes, increased in its strength of association with the severity of the underlying arterial disease; (2) the diabetes and smoking associations with CHD were much stronger in women than men, a phenomenon which, the standardization pattern suggests, is due to a gender difference in CHD pathogenesis, possibly attributable to arteriolar differences.
Outcome in 24 ambulant children with spastic diplegic cerebral palsy, in whom multilevel surgical intervention was recommended following gait analysis, is reviewed. Twelve children had surgical intervention (treatment group; eight males, four females; mean age 9 years 10 months, SD 3 years 4 months) while the other 12 did not (control group; five males, seven females; mean age 10 years 1 month, SD 2 years 11 months). All children had interval three-dimensional gait analyses (mean time between analyses: control group, 14.1 months; treatment group, 17.9 months). At follow-up the control group (mean age 11 years 9 months) showed a significant increase in minimum hip and knee flexion in stance which was not related to age, the interval between analyses, changes in the passive joint range of motion, nor changes in anthropometric measurements. The treatment group (mean age at follow-up 11 years 3 months) showed a significant improvement in minimum knee flexion and in ankle dorsiflexion in stance. Parents of nine children said their child's walking distance had increased following intervention. Of five children using posterior walkers preoperatively, two continued to use them postoperatively; two were using crutches or sticks and the remaining child walked independently. Two children who walked independently preoperatively used sticks postoperatively for community ambulation. The deterioration seen in the kinematics of the control group suggests that previous outcome studies comparing postoperative gait with preoperative gait have underestimated the immediate effects of surgery. It also raises concerns about the long-term effects of surgical intervention.
This paper reports the development, accuracy, reliability, and validation protocol of a four-segment pediatric foot and ankle model. The four rigid body segments include: 1) tibia and fibula; 2) hindfoot--talus, navicular, and calcaneus; 3) forefoot--cuboid, cuneiforms, and metatarsals; and 4) hallux. A series of Euler rotations compute relative angles between segments. Validation protocol incorporates linear and angular testing for accuracy and reliability. Linear static system resolution is greatest in the Y orientation at 0.10 +/- 0.14 mm and 0.05 level of significance and 99.96% accuracy. Dynamic linear resolution and accuracy are 0.43 +/- 0.39 mm and 99.8%, respectively. Angular dynamic resolution computes to 0.52 +/- 3.36 degrees at 99.6% accuracy. These calculations are comparable to the Milwaukee adult foot and ankle model.