PubMed · 13381610
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
C GROBSTEIN. 1956. Inductive tissue interaction in development.. https://doi.org/10.1016/s0065-230x(08)60725-3
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Explore the source record for details and available documents.
Based on the findings of their own studies on embryonic histogenesis of human tissues and published reports, the authors determined the time limits of the existence of human embryonic stem cells and type of their determination in divergent development of tissues in different organs. Realization of genetic information of embryonic stem cells during tissue embryogenesis was studied. This information is realized by the cambium. Variability of all tissue processes is possible only within their own embryonic primordium; prospects of the mesenchyma development in an adult body is discussed.
OBJECTIVE: To investigate whether secretion of soluble human leukocyte antigen-G (HLA-G) by human embryos is associated with embryo development and IVF pregnancy outcome. DESIGN: Retrospective study. SETTING: In vitro fertilization program affiliated with a university research center. PATIENT(S): Infertile couples attending an IVF program were selected. INTERVENTION(S): Embryo culture conditioned medium (72 hours) from cases in which intracytoplasmic sperm injection was used for fertilization. MAIN OUTCOME MEASURE(S): Soluble HLA-G in embryo culture medium samples from IVF patients was assayed and associations between soluble HLA-G secretion and outcome measures were analyzed. RESULT(S): Two hundred seventy of 386 samples had detectable soluble HLA-G. Soluble HLA-G secretion was independent of embryo grade or patients' age. The cleavage rate of embryos secreting soluble HLA-G was significantly higher than that of those lacking it (blastomere number 6.71 +/- 0.09 vs. 5.86 +/- 0.22). The live birth rate from embryos with soluble HLA-G was significantly higher than that of those without (48.4% vs. 17.1%, chi(2) = 9.09). Combining soluble HLA-G detection and cleavage rate was most predictive of pregnancy. CONCLUSION(S): Our five conclusions are as follows: [1] embryonic secretion of soluble HLA-G protein is variable, [2] secretion of HLA-G is correlated with a higher cleavage rate, [3] secretion of HLA-G is associated with a higher pregnancy rate, [4] HLA-G secretion is a better independent predictor than cleavage rate alone, and [5] the combination of soluble HLA-G detection and high cleavage rate was the best predictor of outcome.