PubMed · 13495416
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J LINDENMANN, A ISAACS. 1957. [Research on viral interference].. https://pubmed.ncbi.nlm.nih.gov/13495416/
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We suggest a probabilistic method for comparing the topological features of large phylogenetic trees. Using this method, we demonstrate that a stochastic grammar can generate three influenza-subtype (A H1, A H3, and B) hemagglutinin trees used in an earlier study, with statistically similar parameters. The proposed methodology is applicable to a broad class of problems that require comparison of the topological properties of various dendrograms.
Criteria for classifying influenza viruses into genera, types and subtypes have been discussed, with reference to the 6th report of ICTC. The viruses are divided into 2 genera based on the number of the genome RNA segments. Those which contain 8 segments are further divided into types A or B, according to the antigenicity of the NP and M1 proteins. Viruses belonging to type A are finally classified into subtypes according to the serotype of the HA and NA proteins. Thirteen and nine serotypes of HA and NA, respectively, have been identified in nature, where a variety of combination is possible by genetic reassortment. Method for nomenclature of influenza viruses has also been discussed.