MK-801, a non-competitive antagonist of NMDA receptor, prevents methamphetamine-induced decrease of striatal dopamine uptake sites in the rat striatum.

A Muraki; T Koyama; M Nakayama; T Ohmori; I Yamashita

doi:10.1016/0304-3940(92)90642-k

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MK-801, a non-competitive antagonist of NMDA receptor, prevents methamphetamine-induced decrease of striatal dopamine uptake sites in the rat striatum.

A Muraki·T Koyama·M Nakayama·T Ohmori·I Yamashita

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Abstract

We investigated the effects of MK-801, a non-competitive antagonist of NMDA receptor, on methamphetamine-induced decrease in dopamine (DA) uptake sites in the rat striatum. Repeated administrations of an escalating dose of methamphetamine (2.5, 5, 7.5, 10 mg/kg s.c. x2, every other day for a week) produced decreased DA uptake sites assayed by binding with [3H]GBR 12935 in the striatum. Co-administration of MK-801 and methamphetamine significantly prevented the methamphetamine-induced decrease in striatal [3H]GBR 12935 binding. Administration of MK-801 alone did not affect [3H]GBR 12935 binding. These results suggest that some neurochemical effects of methamphetamine may be mediated via mechanism involving excitatory amino acids.

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Animals Corpus Striatum Dizocilpine Maleate Dopamine Down-Regulation Male Methamphetamine Piperazines Rats Rats, Inbred Strains Receptors, Dopamine Tyrosine 3-Monooxygenase Journal Article Research Support, Non-U.S. Gov't

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A Muraki, T Koyama, M Nakayama, T Ohmori, I Yamashita. 1992-02-17. MK-801, a non-competitive antagonist of NMDA receptor, prevents methamphetamine-induced decrease of striatal dopamine uptake sites in the rat striatum.. https://doi.org/10.1016/0304-3940(92)90642-k

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