Nitric oxide and neurons.

S H Snyder

doi:10.1016/0959-4388(92)90123-3

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Nitric oxide and neurons.

S H Snyder

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Abstract

In the past 2 years powerful evidence has emerged to suggest that nitric oxide functions as a neurotransmitter in both the central and peripheral nervous systems. Recent evidence suggests that it may play a role in mediating forms of synaptic plasticity such as long-term potentiation in the CA1 region of the hippocampus, and long-term depression in the cerebellum. Abnormal secretion of nitric oxide may be responsible for the neurotoxicity mediated by NMDA receptors that results in the pathophysiology of strokes and neurodegenerative diseases.

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Animals Humans Neurons Neurotransmitter Agents Nitric Oxide Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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S H Snyder. 1992. Nitric oxide and neurons.. https://doi.org/10.1016/0959-4388(92)90123-3

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