PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 13546885

[Qualitative studies on tissue ribonucleic acids. III. New method for the separation, quantitative determination and study of the radioactivity of ribonucleotides without previous purification of ribonucleic acid].

M LEDIG·J D WEILL·P MANDEL
View original source ↗Export metadata ↓

Abstract

The source did not provide an abstract. Follow the original record for more information.

Explore related subjects

NucleosidesNucleotidesRNARadioactivityRetinal DegenerationRetinal DetachmentRibonucleotidesNUCLEOSIDES AND NUCLEOTIDES/determinationJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

M LEDIG, J D WEILL, P MANDEL. 1958-06-09. [Qualitative studies on tissue ribonucleic acids. III. New method for the separation, quantitative determination and study of the radioactivity of ribonucleotides without previous purification of ribonucleic acid].. https://pubmed.ncbi.nlm.nih.gov/13546885/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

New synthesis of (+/-)-isonucleosides.

[Structure: see text] A novel method for synthesizing isonucleosides, a new class of anti-HIV nucleosides, is described. 2,2-Dimethyl-1,3-dioxan-5-one was converted into a dioxabicyclohexane derivative in six steps. After cleaving the epoxide group with thiophenol, the resulting product was subjected to the Mitsunobu reaction in the presence of a nucleobase to give the desired isonucleoside derivative via migration of the thiophenyl group. Removal of the thiophenyl group under radical conditions followed by deprotection led to the 4'-substituted 2',3'-dideoxyisonucleosides as a racemic mixture.

Nucleosides↗
PubMed2005

Preparation of nucleoside H-phosphonoselenoate monoesters via the phosphinate approach.

An efficient entry to nucleoside 3'-H-phosphonoselenoate monoesters via phosphinate intermediates was developed. It involves a reaction of suitably protected nucleosides with triethylammonium phosphinate in the presence of pivaloyl chloride, followed by selenization of the intermediate nucleoside phosphinates with triphenylphosphine selenide, to produce the corresponding nucleoside H-phosphonoselenoates in 86-92% yields.

Nucleosides↗
PubMed2005

Double-headed acyclo C-nucleoside analogues. Functionalized 1,2-bis-(1,2,4-triazol-3-yl)ethane-1,2-diol.

Reaction of L-tartaric acid with thiocarbohydcrazide afforded (1R, 2S)-1,2-bis(4-amino-5-mercapto-1,2,4-triazol-3-yl)-ethane-1,2-diol (3). The functional groups in 3 allowed the construction of fused heterocycles on the 1,2,4-triazole rings, mainly of the 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine type as in 4, 5, 7, 10, 13 and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole type as in 14.

Nucleosides↗