PubMed · 13564189
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RADIOLOGICAL notes: case no. 45.. https://pubmed.ncbi.nlm.nih.gov/13564189/
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BACKGROUND: Parathyroid hormone-related protein (PTHrP) is produced by cancer cells and has been suggested to be responsible for malignancy-associated hypercalcemia and osteolysis after bone metatsases. Therefore, PTHrP is a promising target in the treatment of metastatic prostate cancer. METHODS: Seven PTHrP-derived peptides were prepared based on the HLA-A2 binding motif. These peptide candidates were screened by their ability to induce peptide-specific cytotoxic T lymphocytes (CTLs), and their ability to be recognized by immunoglobulin G (IgG). RESULTS: Both the PTHrP59-67 and PTHrP42-51 peptides were found to efficiently induce peptide-specific CTLs from peripheral blood mononuclear cells of HLA-A2+ prostate cancer patients with several HLA-A2 subtypes. These CTLs showed HLA-A2-restricted cytotoxicity toward prostate cancer cells. IgG reactive to the PTHrP42-51 peptide was frequently detected in prostate cancer patients. CONCLUSIONS: These results indicate that these two new PTHrP peptides will be useful in the peptide-based immunotherapy of HLA-A2+ prostate cancer patients, especially those with bone metastases.
Since the early 1980s, limb-sparing procedures have become the standard of care for the treatment of sarcoma involving the extremities. The Tikhoff-Linberg procedure has been described as a limb-sparing option for the treatment of neoplasms of the shoulder girdle. Historically, the involvement of the chest wall with tumor has been considered an absolute contraindication for this operation. We describe a case in which a recurrent sarcoma of the shoulder girdle with chest wall involvement was successfully treated with the Tikhoff-Linberg procedure modified to include chest wall resection, along with a simple reconstructive technique.
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