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PubMed · 1359040

Compliance changes in physiological and pathological states.

F C Yin·C T Ting
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Abstract

AIM: Although arterial compliance has been estimated by a variety of methods none of them can be directly validated because it is difficult to measure arterial volume. Moreover, because arterial pressure-volume relationships are non-linear, compliance is pressure-dependent. We have developed a method of estimating arterial compliance based on the Windkessel model of the arterial system that can account for the pressure-dependence of compliance. RESULTS: Compared to normotensive humans, compliance was decreased in hypertension and normalized with alpha-blockade, angiotensin converting enzyme inhibition and vasodilators, but not with beta-blockade. Compliance changes with aging, exercise and some diseases were determined. CONCLUSION: The decreased compliance seen in hypertension was due to an intrinsic change in the arterial wall, most likely due to increased smooth muscle tone.

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Adrenergic alpha-AntagonistsAdrenergic beta-AntagonistsAdultAgingAngiotensin-Converting Enzyme InhibitorsArteriesBlood PressureComplianceExerciseHumansHypertensionMiddle AgedModels, CardiovascularRegional Blood FlowJournal Article

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F C Yin, C T Ting. 1992. Compliance changes in physiological and pathological states.. https://pubmed.ncbi.nlm.nih.gov/1359040/

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