PubMed · 13605292
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J J THORPE, J T PERRET. 1959. Problem drinking; a follow-up study.. https://pubmed.ncbi.nlm.nih.gov/13605292/
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Association genome scanning can identify markers for the allelic variants that contribute to vulnerability to complex disorders, including alcohol dependence. To improve the power and feasibility of this approach, we report validation of "100k" microarray-based allelic frequency assessments in pooled DNA samples. We then use this approach with unrelated alcohol-dependent versus control individuals sampled from pedigrees collected by the Collaborative Study on the Genetics of Alcoholism (COGA). Allele frequency differences between alcohol-dependent and control individuals are assessed in quadruplicate at 104,268 autosomal SNPs in pooled samples. One hundred eighty-eight SNPs provide (1) the largest allele frequency differences between dependent versus control individuals; (2) t values >or= 3 for these differences; and (3) clustering, so that 51 relatively small chromosomal regions contain at least three SNPs that satisfy criteria 1 and 2 above (Monte Carlo P = 0.00034). These positive SNP clusters nominate interesting genes whose products are implicated in cellular signaling, gene regulation, development, "cell adhesion," and Mendelian disorders. The results converge with linkage and association results for alcohol and other addictive phenotypes. The data support polygenic contributions to vulnerability to alcohol dependence. These SNPs provide new tools to aid the understanding, prevention, and treatment of alcohol abuse and dependence.
The relationship between psychiatric severity and substance use disorders treatment outcome was assessed in 393 individuals who received either standard treatment or standard treatment plus contingency management. The sample was divided into groups of low, moderate, and high psychiatric severity based upon baseline Addiction Severity Index psychiatric composite scores. Participants in the high psychiatric severity group reported a greater prevalence of psychiatric hospitalization, psychiatric medications, and suicide attempts, as well as poorer baseline psychosocial functioning. In terms of treatment outcome, a significant interaction between psychiatric severity and treatment modality was found in relation to treatment retention. Participants in the standard treatment condition were more likely to dropout of treatment earlier as psychiatric severity increased, while retention was similar across the psychiatric severity groups in the contingency management condition. Psychiatric severity was not linked to longest duration of abstinence achieved during treatment or adherence with contingency management procedures. Overall, these findings suggest contingency management is an efficacious and appropriate intervention for substance use disordered individuals across a range of psychiatric problems.
This paper reviews the main toxics which are deleterious to fertility. Toxics are identified through in vitro, animal and clinical studies. The practitioner tries to assess whether a couple consulting for infertility has been exposed to such toxics. Some toxics are voluntarily taken: this is the case for tobacco, alcohol and other, maybe illegal, recreative drugs. Tobacco is the most frequently observed. The assessment of tobacco consumption and the implementation of weaning procedures have been studied in numerous papers: psychological, pharmacological and even immunotherapy-based approaches have been proposed. Alcohol abuse is even more difficult to assess: the border between acceptable convivial and excessive consumption is not clear-cut, except during pregnancy where there should be no alcohol consumption. This also holds for "recreative" drugs. It is usual clinical practice to register the medicine taken; some of these may be toxic for fertility. There is an ongoing work for listing these toxic drugs. Occupational life may also lead to exposure to toxics or be deleterious for fertility by imposing body constraints.