PubMed · 13606684
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B C PAYNE, A M WALDRON. 1958. Essential hyperlipemia.. https://doi.org/10.7326/0003-4819-49-6-1420
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In the present study, an efficient method with a high overall yield for preparing phytosphingosine and an analogue was developed. Starting with commercially available 2,3;5,6-di-O-isopropylidene-d-mannofuranose, a variety of lipid moieties were incorporated to obtain phytosphingosine and an analogue. Through an eight-step manipulation, phytosphingosine was obtained with an overall yield of 57%.
The fusion of biological membranes is governed by the carefully orchestrated interplay of membrane proteins and lipids. Recently determined structures of fusion proteins, individual domains of fusion proteins and their complexes with regulatory proteins and membrane lipids have yielded much suggestive insight into how viral and intracellular membrane fusion might proceed. These structures may be combined with new knowledge on the fusion of pure lipid bilayer membranes in an attempt to begin to piece together the complex puzzle of how biological membrane fusion machines operate on membranes.
Bahiensol (1), a new glycerolipid with antimicrobial activity has been isolated from a cultured plasmodium of myxomycete Didymium bahiense var. bahiense and its planar structure was elucidated by spectral data.