PubMed · 13616101
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N P TIMOSHEV. [Cervical chondroma].. https://pubmed.ncbi.nlm.nih.gov/13616101/
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In the past, six histological grading systems for classical chondrosarcoma have been published. Due to the inhomogeneity and complexity of these classifications, the comparison of clinical data, survival rates and local failures has to be considered critically. In 1996, the author published a grading system that was simple to use and easily reproduced. This system was based on a few nuclear features. The main intention of the current study was to verify whether the histological grade, which was defined by the author's classification, correlates with the recurrence rate. In a retrospective study, clinical data, X-rays and histological material from 35 patients with classical chondrosarcoma and 16 patients with enchondroma were analysed. Statistical analysis was done using the chi-squared test and the Fisher exact test. Local recurrence occurred in 25.7% of all patients. The difference in recurrence rate among grades 1-3 was statistically significant ( P=0.002). The frequency of grades 1-3 varied up to 54%, when published grading systems were compared. No significant difference between the histological grade and features such as double nuclei and mitosis were observed. The frequency of cellularity, double nuclei and mitoses was similar between enchondromas and low-grade chondrosarcomas. Of chondrosarcoma patients, 90.6% of total patients and 87.5% of those with grade-1 lesions reported pain, whereas only 43.8% of the enchondroma patients did. Even in patients with grade-1 chondrosarcomas, radiological findings were much more aggressive in comparison with enchondromas. The histological grade, defined on the basis of the author's simple and reproducible grading system, indicates the risk of local recurrence, especially in cases that are inadequately treated. Grade-3 chondrosarcomas and lesions located in regions where the removal of the tumour would be difficult have to be given special attention.
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Benign solitary neoplasms of the lung are relatively uncommon but nonetheless must be considered in the differential diagnosis of any solitary pulmonary lesion. Ironically, the advent of improved tomographic imaging and its increasingly broad clinical application have led to a greater recognition of benign solitary pulmonary lesions, presenting the surgeon with a complex management dilemma. Most benign lesions are relatively bland radiographically, making their differentiation from carcinoma difficult. Often, diagnostic certainty can only be achieved with complete resection. Fortunately, advances in minimally invasive thoracic surgery make this prospect less daunting for the patient and surgeon. This article reviews a subset of solitary lesions categorized as rare benign neoplasms from histologic, radiographic, and clinical points of view.